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Gene Expression Literature Summary
Assay
Age
In situ RNA (whole mount)
8.5 DPC

11 matching records from 11 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Nkx2-1  NK2 homeobox 1   (Synonyms: T/EBP, thyroid-specific enhancer-binding protein, thyroid transcription factor-1, tinman, Titf1, Ttf-1)
Results  Reference
1J:110605 Camus A, Perea-Gomez A, Moreau A, Collignon J, Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol. 2006 Jul 15;295(2):743-55
1*J:93148 Desai TJ, Malpel S, Flentke GR, Smith SM, Cardoso WV, Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Dev Biol. 2004 Sep 15;273(2):402-15
1J:174727 Fotaki V, Price DJ, Mason JO, Wnt/beta-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects. J Comp Neurol. 2011 Jun 15;519(9):1640-57
1J:42441 Goodrich LV, Milenkovic L, Higgins KM, Scott MP, Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997 Aug 22;277(5329):1109-13
1J:276709 Hashimoto K, Yamaguchi Y, Kishi Y, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K, Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos. Genes Cells. 2019 Jun;24(6):436-448
1J:53291 Hentges K, Thompson K, Peterson A, The flat-top gene is required for the expansion and regionalization of the telencephalic primordium. Development. 1999 Apr;126(8):1601-9
1*J:310130 Jia S, Zhang L, Zhang K, Wang L, Khan A, Zhang J, Sun Y, Wang Y, Song M, Lyu Y, Li M, Lu X, Niu B, Liu Z, Xie J, Nkx2.1 downregulation is involved in brain abnormality induced by excess retinoic acid. Acta Biochim Biophys Sin (Shanghai). 2020 Jun 20;52(6):683-690
1*J:86839 Liguori GL, Echevarria D, Improta R, Signore M, Adamson E, Martinez S, Persico MG, Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak. Dev Biol. 2003 Dec 15;264(2):537-49
1J:99329 Martynoga B, Morrison H, Price DJ, Mason JO, Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol. 2005 Jul 1;283(1):113-27
1J:104523 Ribes V, Wang Z, Dolle P, Niederreither K, Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development. 2006 Jan;133(2):351-61
1*J:31212 Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL, Longitudinal organization of the anterior neural plate and neural tube. Development. 1995 Dec;121(12):3923-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory